Export Citation
Export Citation
Dykes, IM, van Bueren, KL and Scambler, PJ (2017) HIC2 regulates isoform switching during maturation of the cardiovascular system. Journal of Molecular and Cellular Cardiology, 114. pp. 29-37. ISSN 0022-2828
Preview |
Text
HIC2 regulates isoform switching during maturation of the cardiovascular system..pdf - Published Version Available under License Creative Commons Attribution. Download (737kB) | Preview |
Abstract
Physiological changes during embryonic development are associated with changes in the isoform expression of both myocyte sarcomeric proteins and of erythrocyte haemoglobins. Cell type-specific isoform expression of these genes also occurs. Although these changes appear to be coordinated, it is unclear how changes in these disparate cell types may be linked. The transcription factor Hic2 is required for normal cardiac development and the mutant is embryonic lethal. Hic2 embryos exhibit precocious expression of the definitive-lineage haemoglobin Hbb-bt in circulating primitive erythrocytes and of foetal isoforms of cardiomyocyte genes (creatine kinase, Ckm, and eukaryotic elongation factor Eef1a2) as well as ectopic cardiac expression of fast-twitch skeletal muscle troponin isoforms. We propose that HIC2 regulates a switching event within both the contractile machinery of cardiomyocytes and the oxygen carrying systems during the developmental period where demands on cardiac loading change rapidly.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1102 Cardiovascular Medicine And Haematology |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Elsevier |
| Related URLs: | |
| Date of acceptance: | 19 October 2017 |
| Date of first compliant Open Access: | 9 July 2018 |
| Date Deposited: | 09 Jul 2018 11:09 |
| Last Modified: | 04 Sep 2021 10:21 |
| DOI or ID number: | 10.1016/j.yjmcc.2017.10.007 |
| URI: | https://ljmu-9.eprints-hosting.org/id/eprint/8933 |
 |
View Item |