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Perry, CGR and Hawley, JA (2017) Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges. Cold Spring Harbor Perspectives in Medicine. ISSN 2157-1422
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Abstract
We provide an overview of groundbreaking studies that laid the foundation for our current understanding of exercise-induced mitochondrial biogenesis and its contribution to human skeletal muscle fitness. We highlight the mechanisms by which skeletal muscle responds to the acute perturbations in cellular energy homeostasis evoked by a single bout of endurance-based exercise and the adaptations resulting from the repeated demands of exercise training that ultimately promote mitochondrial biogenesis through hormetic feedback loops. Despite intense research efforts to elucidate the cellular mechanisms underpinning mitochondrial biogenesis in skeletal muscle, translating this basic knowledge into improved metabolic health at the population level remains a future challenge.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport and Exercise Sciences |
| Publisher: | Cold Harbor Laboratory Press |
| Related URLs: | |
| Date of acceptance: | 15 May 2017 |
| Date of first compliant Open Access: | 3 January 2018 |
| Date Deposited: | 03 Jan 2018 11:39 |
| Last Modified: | 04 Sep 2021 10:53 |
| DOI or ID number: | 10.1101/cshperspect.a029686 |
| URI: | https://ljmu-9.eprints-hosting.org/id/eprint/7751 |
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