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Nielsen, LH, Nagstrup, J, Gordon, S, Keller, SS, Østergaard, J, Rades, T, Müllertz, A and Boisen, A (2015) pH-triggered drug release from biodegradable microwells for oral drug delivery. Biomedical Microdevices, 17 (3). ISSN 1572-8781
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Abstract
Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastro-resistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract. Biorelevant gastric medium (pH 1.6) was employed, after which a change to biorelevant intestinal release medium (pH 6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium. An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system.
| Item Type: | Article |
|---|---|
| Additional Information: | The final publication is available at Springer via http://dx.doi.org/10.1007/s10544-015-9958-5 |
| Uncontrolled Keywords: | 0903 Biomedical Engineering, 0912 Materials Engineering |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Springer Verlag |
| Related URLs: | |
| Date of acceptance: | 16 May 2015 |
| Date of first compliant Open Access: | 5 June 2017 |
| Date Deposited: | 05 Jun 2017 11:24 |
| Last Modified: | 18 May 2022 10:37 |
| DOI or ID number: | 10.1007/s10544-015-9958-5 |
| URI: | https://ljmu-9.eprints-hosting.org/id/eprint/6627 |
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