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Wainwright, M (2015) Tricyclic Cationic Chromophores as Models for New Photoantimicrobials. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 26 (12). pp. 2390-2404. ISSN 0103-5053
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Abstract
Despite the preponderance of literature pertaining to photosensitisers based on the porphyrin system, many other chemical classes are available with similar or improved characteristics and potential for use in photodynamic medicine. Several of these classes are based on small, tricyclic, heteroaromatic chromophores, often originally developed from textile dyes or biological stains. The latter classification is useful in providing a basis for biological uptake and antimicrobial activity. The current review covers the chemistry and photoantimicrobial applications of established and novel cationic bisamino derivatives of the acridine, phenazine, phenoxazine, phenothiazine and xanthene systems and related compounds. The range covered is considerable and demonstrates photodynamic performance to rival the porphyrin class. In addition, the chemical synthesis of new analogues of lead compounds such as methylene blue or acridine orange is relatively straightforward and inexpensive, and compound series with varying physicochemical profiles have been produced for structure-activity studies in order to furnish improved photosensitisers for clinical trialling
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 03 Chemical Sciences |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Brazilian Chemical Society |
| Related URLs: | |
| Date of acceptance: | 28 July 2015 |
| Date of first compliant Open Access: | 7 March 2016 |
| Date Deposited: | 07 Mar 2016 09:36 |
| Last Modified: | 03 Aug 2022 08:59 |
| DOI or ID number: | 10.5935/0103-5053.20150188 |
| URI: | https://ljmu-9.eprints-hosting.org/id/eprint/3070 |
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