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Gajewicz, A, Cronin, MTD, Rasulev, B, Leszczynski, J and Puzyn, T (2015) Novel approach for efficient predictions properties of large pool of nanomaterials based on limited set of species: nano-read-across. NANOTECHNOLOGY, 26 (1). pp. 1-9. ISSN 0957-4484
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Abstract
Creating suitable chemical categories and developing read-across methods, supported by quantum mechanical calculations, can be an effective solution to solving key problems related to current scarcity of data on the toxicity of various nanoparticles. This study has demonstrated that by applying a nano-read-across, the cytotoxicity of nano-sized metal oxides could be estimated with a similar level of accuracy as provided by quantitative structure-activity relationship for nanomaterials (nano-QSAR model(s)). The method presented is a suitable computational tool for the preliminary hazard assessment of nanomaterials. It also could be used for the identification of nanomaterials that may pose potential negative impact to human health and the environment. Such approaches are especially necessary when there is paucity of relevant and reliable data points to develop and validate nano-QSAR models
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MD Multidisciplinary |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | IOP PUBLISHING LTD |
| Related URLs: | |
| Date of acceptance: | 7 October 2014 |
| Date of first compliant Open Access: | 15 February 2016 |
| Date Deposited: | 15 Feb 2016 11:02 |
| Last Modified: | 04 Sep 2021 13:25 |
| DOI or ID number: | 10.1088/0957-4484/26/1/015701 |
| URI: | https://ljmu-9.eprints-hosting.org/id/eprint/2932 |
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