Synthesis and structure-activity-relationships of indan acid derivatives as analgesic and anti-inflammatory agents

Bachar, SC, Nahar, L and Sarker, SD (2016) Synthesis and structure-activity-relationships of indan acid derivatives as analgesic and anti-inflammatory agents. Review Journal of Chemistry, 6 (2). pp. 125-138. ISSN 2079-9799

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Abstract

Indan ring system, also known as indane or benzocyclopentane, is an important chemical feature associated with various biological activities. Among the drugs possessing an indan ring system, 1H-indene-3-acetic acid-5-fluoro-2-methyl-1-[4-(methylsulfinyl)-phenyl]methylene (Sulindac) and 6-chloro-5-cyclohexyl indan-1-carboxylic acid (Clidanac) are well known anti-inflammatory agents, whilst indan-1,3-dione is an anticoagulant. Over the years, several indan derivatives, particularly indan acid derivatives, have been synthesized and their potential analgesic and anti-inflammatory properties have been studied. This review critically appraises various synthetic protocols and structure-activity-relationships of indan acids as analgesic and anti-inflammatory agents with low ulcerogenicity.

Item Type:	Article
Additional Information:	The final publication is available at Springer via http://dx.doi.org/10.1134/S2079978016020011
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Springer Verlag
Date of acceptance:	4 January 2016
Date of first compliant Open Access:	20 May 2017
Date Deposited:	01 Feb 2016 12:19
Last Modified:	04 Sep 2021 13:31
DOI or ID number:	10.1134/S2079978016020011
URI:	https://ljmu-9.eprints-hosting.org/id/eprint/2797

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