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Ajibade, PA, Fatokun, AA and Paca, AM (2023) Synthesis, crystal structure, and anticancer studies of organoruthenium(II) p-cymene N-phenyldithiocarbamate complex. Journal of Molecular Structure, 1292. ISSN 00222860
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Synthesis crystal structure and anticancer studies of organoruthenium p-cymene N-phenyldithiocarbamate complex.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (2MB) | Preview |
Abstract
Organoruthenium(II) p-cymene N-phenyldithiocarbamate complex, [Ru(phdtc)(η⁶-p-cym)]₂, was synthesized and characterized by elemental analysis, spectroscopic techniques, and single crystal X-ray crystallography. The single crystal X-ray structure of the complex shows that the compound crystallizes in a monoclinic crystal system with a P21/c space group to form a centrosymmetric binuclear complex. The structure consists of two divalent ruthenium(II) ions, two N-phenyldithiocarbamato anions and two p-cymene molecules. Each N-phenyldithiocarbamato anion acts as a chelating ligand to one ruthenium(II) and a bridging ligand to second ruthenium(II) ion in a classic “three-legged piano-stool” arrangement with a pseudo-tetrahedral geometry. The geometry around the ruthenium(II) ions is completed through η6 coordination to the p-cymene carbon atoms. Anticancer studies showed that the compound is potently cytotoxic (complete kill between 10 and 50 μM) when tested up to 100 μM for up to 48 h against two cell lines, HeLa and MRC5-SV2, models of cervical and lung cancer, respectively, and in some instances outperformed the standard platinum-based anticancer drug cisplatin for cytotoxic potency, highlighting the anti-cancer prospect of the complex.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Elsevier |
| Date of acceptance: | 13 July 2023 |
| Date of first compliant Open Access: | 28 July 2023 |
| Date Deposited: | 28 Jul 2023 15:08 |
| Last Modified: | 28 Jul 2023 15:15 |
| DOI or ID number: | 10.1016/j.molstruc.2023.136102 |
| URI: | https://ljmu-9.eprints-hosting.org/id/eprint/20383 |
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