Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens

Escher, S, Felter, SP, Hollnagel, H, Boobis, AR, Yang, C, Rathman, J, Cronin, MTD and Batke, M (2023) Workshop report on the evaluation of the updated and expanded carcinogen database to support derivation of threshold of toxicological concern values for DNA reactive carcinogens. ALTEX, 40 (2). ISSN 1868-596X

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Abstract

Threshold of toxicological concern (TTC) values are frequently used for compounds occurring at low concentrations in feed and food or as impurities in drugs. This workshop report addresses the emerging alternatives for deriving TTC values for DNA reactive carcinogens and evaluating the acceptability of the Cramer Class TTC values to be adequately protective for non-DNA reactive carcinogens.

Item Type:	Article
Uncontrolled Keywords:	07 Agricultural and Veterinary Sciences; 11 Medical and Health Sciences; Toxicology
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	ALTEX Edition
Date of acceptance:	11 November 2022
Date of first compliant Open Access:	18 November 2022
Date Deposited:	18 Nov 2022 10:25
Last Modified:	03 Apr 2023 08:15
DOI or ID number:	10.14573/altex.2210111
URI:	https://ljmu-9.eprints-hosting.org/id/eprint/18162

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