Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population: a nationwide observational, cross-sectional study

Krzemień, P, Kasperczyk, S, Banach, M, Kasperczyk, A, Dobrakowski, M, Tomasik, T, Windak, A, Mastej, M, Catapano, A, Ray, KK, Mikhailidis, DP, Toth, PP, Howard, G, Lip, GYH, Tomaszewski, M, Charchar, FJ, Sattar, N, Williams, B, MacDonald, TM, Penson, PE et al (2021) Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population: a nationwide observational, cross-sectional study. Rheumatology International. ISSN 0172-8172

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Abstract

The detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. The aim of the study was first to assess the prevalence of ANA in the Polish adult population depending on age, sex and the cutoff threshold used for the results obtained. Second, we estimated the occurrence of individual types of ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA using two cutoff thresholds of 1:100 and 1:160. We found ANA in 260 participants (15.0%), but the percentage of positive results strongly depended on the cutoff level. For a cutoff threshold 1:100, the positive population was 19.5% and for the 1:160 cutoff threshold, it was 11.7%. The most prevalent ANA-staining pattern was AC-2 Dense Fine speckled (50%), followed by AC-21 Reticular/AMA (14.38%) ANA more common in women (72%); 64% of ANA-positive patients were over 50 years of age. ANA prevalence in the Polish population is at a level observed in other highly developed countries and is more prevalent in women and elderly individuals. To reduce the number of positive results released, we suggest that Polish laboratories should set 1:160 as the cutoff threshold.

Item Type:	Article
Uncontrolled Keywords:	1103 Clinical Sciences
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Springer
Date of acceptance:	13 October 2021
Date of first compliant Open Access:	10 November 2021
Date Deposited:	10 Nov 2021 11:22
Last Modified:	10 Nov 2021 11:30
DOI or ID number:	10.1007/s00296-021-05033-9
URI:	https://ljmu-9.eprints-hosting.org/id/eprint/15773

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