Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)

Cirilli, I, Damiani, E, Dludla, PV, Hargreaves, IP, Marcheggiani, F, Millichap, LE, Orlando, P, Silvestri, S and Tiano, L (2021) Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020). Antioxidants, 10 (8). ISSN 2076-3921

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Abstract

The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease. Classical antioxidant and bioenergetic functions of the coenzyme have been taken into consideration, as well as novel mechanisms of action involving the redox-regulated activation of molecular pathways associated with anti-inflammatory activities. Cardiovascular research and fertility remain major fields of application of Coenzyme Q10, although novel applications, in particular in relation to topical application, are gaining considerable interest. In this respect, bioavailability represents a major challenge and the innovation in formulation aspects is gaining critical importance.

Item Type:	Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	MDPI AG
Date of acceptance:	20 August 2021
Date of first compliant Open Access:	2 September 2021
Date Deposited:	02 Sep 2021 10:31
Last Modified:	04 Sep 2021 05:05
DOI or ID number:	10.3390/antiox10081325
URI:	https://ljmu-9.eprints-hosting.org/id/eprint/15433

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