Saussureae involucratae Herba (Snow Lotus): Review of chemical compositions and pharmacological properties

Gong, G, Huang, J, Yang, Y, Qi, B, Han, G, Zheng, Y, He, H, Chan, K, Tsim, KWK and Dong, TTX (2020) Saussureae involucratae Herba (Snow Lotus): Review of chemical compositions and pharmacological properties. Frontiers in Pharmacology, 10. ISSN 1663-9812

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Abstract

Saussureae Involucratae Herba is the dried ground part of Saussurea involucrata (Kar. et Kir.) Sch.-Bip, which is also named as “Snow lotus” and being used in traditional Uyghur and/or Chinese medicine. This rare herb can be found at 4,000 m elevation in western part of Tianshan Mountain, Xinjiang China. According to China Pharmacopoeia (2015), the major pharmaceutical values of “Snow lotus” (Xuě liánhuā in Chinese) are alleviating rheumatoid arthritis, accelerating blood circulation and mitigating other “cold” syndromes. Traditionally, the clinical application of “Snow lotus” includes the treatments in inflammation-associated disorder, blood circulation acceleration and heat and dampness elimination. Recent studies suggested that “Snow lotus” possessed therapeutic effects associating with anti-cancer, anti-oxidation, adipogenesis suppression and neuroprotection activities, which were proposed to be related with its bioactive constitutes, i.e. acacetin, hispidulin, and rutin. In the present review, we aim to summarize pharmacological effects and underlying cell signaling pathways of “Snow lotus” in treating various medical problems. Copyright © 2020 Gong, Huang, Yang, Qi, Han, Zheng, He, Chan, Tsim and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Item Type:	Article
Uncontrolled Keywords:	1115 Pharmacology and Pharmaceutical Sciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Frontiers Media
Date of acceptance:	29 November 2019
Date of first compliant Open Access:	11 February 2020
Date Deposited:	11 Feb 2020 11:42
Last Modified:	04 Sep 2021 07:55
DOI or ID number:	10.3389/fphar.2019.01549
URI:	https://ljmu-9.eprints-hosting.org/id/eprint/12239

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